Sherlock Holmes says in “<a href=http://www.gutenberg.org/files/1661/1661-h/1661-h.htm#11>The Adventure of the Beryl Coronet</a>”:
“It is an old maxim of mine that when you have excluded the impossible, whatever remains, however improbable, must be the truth.”
Outside of mathematics, one can never know the gamut of the conceivable so as to exclude it.
There is always the unknown unknown, unless you are doing math where you have created the world.

<a href=http://dinosaurtheory.com/theory.html>This paper</a> is also skeptical.